But five is so much better than one!I totally get the desire to have the one can to rule them all (something I wish I had thought of before I got into suppressors, now that I have 5 of them), but you might just want to get a dedicated .22 can if you'll be doing a lot of .22 suppressed. I think you might be happier with the results.
I just bought my second. I imagine there will be more in my future as well.