my glock 22 w/15rds hornaday and my home built ar15 w/30rds of 55gr vmax hand loads .OH! and Loki and Ireland my dobermans says what about us . there my first line of defense . they are really cranky when they get woke up.
Sig P226 TacOps, 4 twenty round mags (standard, of course), loaded with 81 rounds of federal tactical LE +p 9mm and a 350 lumen lightsaber (sig stoplite) with a strobe mode option that'd blind a rhino.
Everything else I would have to stand up to reach.
That would depend on if it's my side of the bed or the wife's, which bed or if I was sleeping on the couch. M&P 40, Taurus Titanium snub nose 38 revolver or LLama 380 depending.