It breaks down to gun control. Place your shot where it will be the MOST effective.
If you are to the point you need to shoot, one to the forehead almost ALWAYS eliminates the concern about "knockdown power".
If you still don't feel the need to take a life, the knees are a perfect "take-down" shot.
Once again, shot placement = gun control.
A shot with a service caliber to the pelvic girdle area will generally drop an adversary like a used rubber. It may not kill them but chances are good they will go down.