In my experience, yes. The manual recommends a 200-round break-in, and I do follow this advice. That said, my PM9 was 100% reliable, even in the break-in period. My MK40 has also been 100%. My CM9 had 2 failures to feed in the first magazine, and has been fine thereafter.
I think Kahrs are among the most reliable pocket autos. Like all small guns, they should be properly broken in and kept clean to ensure reliability.