Just be sure the company is using a bullet made for that speed. Some are simply recycling their 9mm bullet, and it opens too fast or fragments if they push it to the .357 capability, so they download it to basically a 9mm +P with reduced capacity.
Personally, I wouldn't carry them for self defense. I haven't seen a .45 used yet, but the 9mm does not do well on bone. It hit, it did break the bone, but it was stopped and fragmented so dramatically that it did not penetrate further and just made a very shallow, but very messy, wound. A soft tissue hit may be nasty, I don't know, but when they are stopped by small bone I'm not carrying them.
Seemed to be a good idea such as a glaser for inside the house. I would hate to have a round get outside and do damage or worse yet, hurt.
They are so very lite. A full box seems empty compared to other .45 SD rounds.