Yes!
Fear the man who hits 10 out of 10 times on a 8 inch paper plate because he knows that he will get the job done.
I was at my best friends house yesterday and he had his neighbor over that had a Taurus .454 Casull and was bragging about taking down anybody with it. All over the paper to the left and right with 1 to the top left that might have made some contact on a shoulder part, nothing inside of the 5 ring. I went after him and he wanted to change the target for me so I'd have a fresh one to see my hits.
I told him we don't waste targets here and promptly put 17 shots within the 7 ring at 35 feet. Walked up, pulled the target off and handed it to him, and let him know that he has to hit it first to take it down. Before the end of the shoot he was firmly entrenched in the idea that he needs to get a more controllable gun.
Shot placement is everything unless you get lucky and blow out a femoral or other major artery.
My CCW has been a 9mm for a long time. Federal 9BPLE has a good track record, hope I never have to test it, but feel it will be there if needed.