ANYTHING Hanna wants for a weapon in the movie "Hanna". If you haven't seen it, hang on to your hat. I call it a female "Bourne Identity". Stupid in spots, brilliant in others.
Obviously Vera, was & still am a big fan of the cancelled Firefly TV series & the later Serenity movie.
But a big fan of any 1911, since no ones mentioned the supressed 1911's from the movie "Hitman"...I'll go with these also.
(Bonus points if you recognize US Marshall Raylan Givens without his cowboy hat)
For me, it is a tie between this and the mini gun carried by Jesse Ventura in Predator, "Ole' Painless." I loved the way it mowed down the rainforest! :-)