I would strongly suggest you let her shoot as many different guns as possible, then let her decide what works for her.
You mentioned she has some wrist issues. You may want to think about a heavier gun. My wife has some wrist problems as well, but can shoot her GP100 all day long. On the other hand, she refuses to ever shoot my M&P .40 again because of the snappier recoil. Not a hard and fast rule, but something you may want to think about.
I would take her shooting for sure before buying her a gun. Also if she is comfortable with the idea of carring a pistol, after shooting one, let her pick her own out, My wife is 69 years old and cannot operate the slide on any of my autoloaders. She is deadly with a revolver, and can shoot very well with one of those. When we were young the wife and I shot a .22 pistol a lot, she has not used one in years. This last year she got her carry permit, or license to carry a hand gun. I took her to a friendly Gun Shop I know and the lady working there showed her a Ruger LCR with a Laiser grip on it, it was love at first sight. Now my shooting buddy The Retired Army guy is on tap to teach her to use it.
Bill...