Sure there are. A 45 acp wheelgun you'll have to use moonclips. Could go 45longcolt. Ammo is expensive either way. 357 is a great all around cartridge. No moonclips. Somewhat cheaper ammo And available in a wide range of frame sizes. From small to large.
I like the 357 because it will shoot 38 special ammo. I have most always used 38 special reloaded semi wadcutters for target practice & Winchester silver tips for carry. The 38 special ammo is quite a bit cheaper to shoot.
Don't shoot without hearing protection.Noise factor is brutal with the magnums without hearing protection. They all will damage your hearing if you aren't careful. Good luck.