I only ask as a pistol with no manual safety to me is an issue. You have discovered why I have that opinion.
My night stand gun is a 1911 (go figure) and has to be manipulated to fire it. Not saying it could not happen as I have many many hours with this platform just saying it is another barrier between me and an AD.
I do hope your having the gun in a safe does not cause you issue should the need arise to use it in defense of house/family.
You are the one that knows what your needs are.
My Sig is SA/DA and when in DA has a long trigger pull before it will shoot and I felt safe with that (still do).I would never carry it in SA mode with one in the chamber. The trigger pull is not very long in SA. I would of like to of had a manual safety and normally I would not have a gun with no thumb safety,but I was sold on that Sig when I first had a chance to handle it at the store. I feel very safe with it in DA and will always carry it with me with one chambered.Just not chambered when I go to bed or away from the house.