I carry either a Browning HiPower Mk III (has an ambi safety), or a Beretta 92FS that has an ambi decocker (and I switched the mag release to lefty - you can do that with a 92FS). Over the years I've adapted to dropping mags with my trigger finger instead of my thumb, and I "slingshot" the slide on reloads, so I just about never use the actual slide release.
My next pistol will be a CZ-85B or 85 Combat. That one has an ambi safety AND slide release.