I have been going through the same with my wife. Start out by letting her hold as many guns as possible and seeing what she likes the feel of and what is comfortable with her. A lot of women seem to be fond of 1911's and I would suggest you start her out with a 9mm as it is not too much of a gun for the majority of women. Some will not like it, but it's not too much for them to handle to see what they think. From there you can increase or decrease caliber as necessary. Something is better than nothing, but from a ballistics and field experience stand point I would suggest that if you must go smaller than 9mm a .38 revolver is going to be more effective with the right ammo than 380. I too have been going through a list of compact 1911's in 9mm and introducing them to my wife and between the options the best one for the price IMO is the Colt New Agent. Another one which seems to be popular with women is the Sig 238. The best thing you can do is introduce her to a huge variety and let her shoot as much/many as possible because holding it may feel comfortable to a woman, but shooting it is going to be a whole other story.