While I don't shoot at 300+ yards anymore I have had stability issues with bullets really open up groups at 150 that looked good at 100. Marlin 1894s do this in 44 mag with bulllets when they start getting heavier that 250 grains. I have not tried the Lee 300 RNF but would imagine this would have this problem in 44 mag. One of my planned retirement projects is to try this bullet in 444.
Heck, some 250 grains in my 1894 .44 keyhole at 100. But great point. It is only applicable if spin rate is enough to continue to stabilize out to the desired distance.