It's all about shot placement and an effective weapon/ammo combination. My first preference would always be my shotgun or AR in 6.8 but the guns will not fit in my pocket. Thus I have to rely on handguns when out and about. I was required to carry the 1911 in the early 70s in the military but fortunately was not assigned a post in harms way. If such an assignment had been made, I would have also kept a M16 handy. The 1911 was a bit big for my smallish hands but I had no difficulty qualifying with the weapon. With the continual improvement of ammo, I am much more comfortable with calibers of smaller stature that the 45 acp., when one compares contemporary stopping power of the various calibers of modern ammo.