Always enjoy reading the "WHAT AMMO is best..." threads.
1. IT HAS TO RUN IN YOUR GUN... PERIOD.
2. GIVEN That...Anything on Doc Gary Roberts list for a given caliber (read link below for IN DEPTH analysis)
Best Choices for Self Defense Ammo
Of note Critical Defnse or Duty is NOT on the list.
3. SHOT PLACEMENT is CRITICAL, NO MATTER WHAT Unobtanium HEI fragmenting submunition tungsten penetrator rounds you are using. A FMJ hit high COM is better than a HST +P to the big toe.
4. SD Bullet selection is not JUST about terminal ballistics, it is also about NOT OVERPENETRATING into uninted targets.