PLEASE compare the value of your life to an inadequate caliber handgun and reevaluate your carry options.
While I have several .22lr firearms, long and short, and they are great for their intended uses, SD is NOT one of them - and that is why ammo manufactures don't produce SD ammo for .22's - if they do, its just advertising propaganda BS.
There are dozens of compact carry models of service caliber in all price ranges.
To each there own, but JMO I ONLY carry .38+P 150gr or 9mm 147gr as a BUG. .22 & .22lr should only be used in plinking or small critter removal.