Huh, that really is an odd powder choice for the 22-250. In fact, that just doesn't sound right at all. Neither Hodgdon, nor Lyman, shows 4198 with any bullet weight for that cartridge. Why such a fast powder?
QuickLoad is predicting only ~33,000psi with that charge, and about 3,500fps. I guess that's plenty fast for the lighter 40gr bullets?